In vivo functions of integrins: lessons from null mutations in mice.

@article{Sheppard2000InVF,
  title={In vivo functions of integrins: lessons from null mutations in mice.},
  author={Dean Sheppard},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2000},
  volume={19 3},
  pages={
          203-9
        }
}
The integrin family (Hynes, R.O., 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25) is composed of at least 24 heterodimers formed from eight beta subunits and 18 alpha subunits. Thus far, mice expressing null mutations of seven of the eight beta subunits and 13 of the 18 known alpha subunits have been generated, With only a few exceptions, the phenotypes of each of the knockout lines are quite distinct. Studies utilizing integrin knockout mice and cells… CONTINUE READING
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