In vivo functions of GPR30/GPER-1, a membrane receptor for estrogen: from discovery to functions in vivo.

@article{Mizukami2010InVF,
  title={In vivo functions of GPR30/GPER-1, a membrane receptor for estrogen: from discovery to functions in vivo.},
  author={Yoichi Mizukami},
  journal={Endocrine journal},
  year={2010},
  volume={57 2},
  pages={101-7}
}
G protein-coupled receptor 30/G protein-coupled estrogen receptor-1 (GPR30/GPER-1) was reported as a novel membrane receptor for estrogen in 2005. However, the research on GPR30 has produced conflicting reports with regard to its intracellular localization, the tissue distribution of its expression, and some its functions. Recently, in addition to the finding of G-1, a GPR30 agonist, GPR30 KO mice have been produced in laboratories, and this has significantly increased the confidence in the… CONTINUE READING

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Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin

Martensson uE, Salehi Sa, +16 authors LM Leeb-Lundberg
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G protein - coupled receptor 30 : estrogen receptor or collaborator ?

ER Levin
Endocrinology • 2009

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