In vivo functional microangiography by visible-light optical coherence tomography.

@article{Yi2014InVF,
  title={In vivo functional microangiography by visible-light optical coherence tomography.},
  author={Ji Yi and Siyu Chen and Vadim Backman and Hao F. Zhang},
  journal={Biomedical optics express},
  year={2014},
  volume={5 10},
  pages={3603-12}
}
Although hemoglobin oxygen saturation (sO2) in the microvasculature is an essential physiological parameter of local tissue functions, non-invasive measurement of microvascular sO2 is still challenging. Here, we demonstrated that visible-light optical coherence tomography (vis-OCT) can simultaneously provide three-dimensional anatomical tissue morphology, visualize microvasculature at the capillary level, and measure sO2 from the microvasculature in vivo. We utilized speckle contrast caused by… CONTINUE READING