In vivo functional differences in microvascular response of 4T1 and Caki-1 tumors after treatment with OXi4503.

@article{Wankhede2010InVF,
  title={In vivo functional differences in microvascular response of 4T1 and Caki-1 tumors after treatment with OXi4503.},
  author={Mamta Wankhede and Casey Dedeugd and Dietmar W. Siemann and Brian S. Sorg},
  journal={Oncology reports},
  year={2010},
  volume={23 3},
  pages={685-92}
}
4T1 mouse mammary adenocarcinomas and Caki-1 human renal cell carcinomas grown in mouse dorsal window chambers were serially treated with the vascular disrupting agent (VDA) OXi4503 and their responses compared. The real-time in vivo response was assessed using spectral imaging of microvascular hemoglobin saturation. To our knowledge this is the first use of spectral imaging technology for investigation of vascular disrupting agents. Previous research showing tumor size dependence in the… CONTINUE READING

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