In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine.

@article{Souliotis1991InVF,
  title={In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine.},
  author={Vassilis L. Souliotis and Vassiliki A Boussiotis and Gerassimos Alexander Pangalis and Soterios A Kyrtopoulos},
  journal={Carcinogenesis},
  year={1991},
  volume={12 2},
  pages={285-8}
}
Blood leukocyte DNA obtained from 11 Hodgkin's disease patients undergoing ABVD chemotherapy was analysed for the presence of the precarcinogenic adduct O6-methylguanine (O6-meG) at various times (1-2 h up to 49 h) after i.v. treatment with the methylating drug dacarbazine. Adduct formation was detected in all but one of the patients examined at levels ranging up to 0.45 fmol/micrograms DNA (7.2 x 10(-7) mol/mol guanine). The levels of the adduct decreased by approximately 30% over the 24 h… CONTINUE READING
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