In vivo fluorometric assessment of cyclosporine on mitochondrial function during myocardial ischemia and reperfusion.

Abstract

BACKGROUND Cyclosporine A (CsA) limits myocardial reperfusion injury and preserves mitochondrial integrity, but its influence on mitochondrial function has not been described in vivo. Auto-fluorescence of mitochondrial nicotinamide adenine dinucleotide and flavin adenine dinucleotide correlate with mitochondrial dysfunction. We hypothesized that CsA limits… (More)
DOI: 10.1016/j.athoracsur.2010.01.065

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