In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma.

@article{Ullrich2014InVF,
  title={In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma.},
  author={Martin Ullrich and R. P. H. M. Bergmann and Mirko Peitzsch and Marc Cartellieri and Nan Qin and Monika Ehrhart-Bornstein and Norman L . Block and Andrew V Schally and Jens Pietzsch and Graeme Eisenhofer and Stefan R. Bornstein and Christian G. Ziegler},
  journal={Endocrinology},
  year={2014},
  volume={155 11},
  pages={4149-56}
}
Pheochromocytoma (PHEO) is a rare but potentially lethal neuroendocrine tumor arising from catecholamine-producing chromaffin cells. Especially for metastatic PHEO, the availability of animal models is essential for developing novel therapies. For evaluating therapeutic outcome in rodent PHEO models, reliable quantification of multiple organ lesions depends on dedicated small-animal in vivo imaging, which is still challenging and only available at specialized research facilities. Here, we… CONTINUE READING
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