In vivo fatigue loading of the rat ulna induces both bone formation and resorption and leads to time-related changes in bone mechanical properties and density.

@article{Hsieh2002InVF,
  title={In vivo fatigue loading of the rat ulna induces both bone formation and resorption and leads to time-related changes in bone mechanical properties and density.},
  author={Yeou-Fang Hsieh and M. J. Vaz-da Silva},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2002},
  volume={20 4},
  pages={764-71}
}
Fatigue loading triggers bone resorption and is associated with stress fractures. Neither the osteogenic response nor the changes in bone mechanical properties following in vivo fatigue loading have been quantified. To further characterize the skeletal response to fatigue loading, we assessed bone formation, mechanical properties, density and resorption in the ulnae of 72 adult rats subjected to a single bout of in vivo loading followed by 0, 6, 12 or 18 days of recovery. Axial, compressive… CONTINUE READING

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