In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes.

@article{Bellingan1996InVF,
  title={In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes.},
  author={Geoffrey John Bellingan and Helen Caldwell and Sarah E. M. Howie and Ian Dransfield and Christopher Haslett},
  journal={Journal of immunology},
  year={1996},
  volume={157 6},
  pages={2577-85}
}
The resolution of acute inflammation requires bulk clearance of extravasated inflammatory cells in an ordered manner. Neutrophils undergo apoptosis and are ingested by macrophages (M psi) via a novel recognition mechanism that fails to provoke proinflammatory responses. Thereafter, the fate of inflammatory M psi themselves remains unclear. We investigated this in vivo, developing a semiallogeneic adoptive transfer system to track the fate of inflammatory M psi in a murine model of resolving… CONTINUE READING
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