In vivo fate of superparamagnetic iron oxides during sepsis.

@article{Fujii2002InVF,
  title={In vivo fate of superparamagnetic iron oxides during sepsis.},
  author={H. Fujii and K. Yoshikawa and L. Berliner},
  journal={Magnetic resonance imaging},
  year={2002},
  volume={20 3},
  pages={
          271-6
        }
}
The enzymatic generation of nitric oxide (NO) in vivo has been reported to be modulated by ions, such as copper and iron. Superparamagnetic iron oxide (SPIO) or ferumoxides is a liver-specific magnetic resonance contrast agent that is taken up by the Kupffer cells, where NO is generated by inducible nitric oxide synthase (iNOS). Thus, it is important to evaluate SPIO in vivo under conditions, such as infectious disease, where significant amounts of NO are generated by iNOS. In this study, we… Expand
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