In vivo far-red luminescence imaging of a biomarker based on BRET from Cypridina bioluminescence to an organic dye.


We aimed to develop a far-red luminescence imaging technology for visualization of disease specific antigens on cell surfaces in a living body. First, we conjugated a far-red fluorescent indocyanine derivative to biotinylated Cypridina luciferase. This conjugate produced a bimodal spectrum that has long-wavelength bioluminescence emission in the far-red… (More)
DOI: 10.1073/pnas.0908594106


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