In vivo expression profile of an endothelial nitric oxide synthase promoter-reporter transgene.

@article{Teichert2000InVE,
  title={In vivo expression profile of an endothelial nitric oxide synthase promoter-reporter transgene.},
  author={A M Teichert and Tricia L Miller and Sharon C Tai and Yibin Wang and Xiaoshu Bei and Gregory B. Robb and Melville J Phillips and Philip A. Marsden},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 4},
  pages={H1352-61}
}
Endothelium-derived nitric oxide (NO) is primarily attributable to constitutive expression of the endothelial nitric oxide synthase (eNOS) gene. Although a more comprehensive understanding of transcriptional regulation of eNOS is emerging with respect to in vitro regulatory pathways, their relevance in vivo warrants assessment. In this regard, promoter-reporter insertional transgenic murine lines were created containing 5,200 bp of the native murine eNOS promoter directing transcription of… CONTINUE READING