In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin-1 beta.

@article{Hutchinson1992InVE,
  title={In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin-1 beta.},
  author={N I Hutchinson and Michael W. Lark and Karen L Macnaul and Caroline Harper and L A Hoerrner and Jim McDonnell and Susanna Donatelli and Vernon L. Moore and Ellen K Bayne},
  journal={Arthritis and rheumatism},
  year={1992},
  volume={35 10},
  pages={1227-33}
}
OBJECTIVE To examine the in vivo expression of the matrix metalloproteinase stromelysin in the synovium and articular cartilage of rabbits injected intraarticularly with recombinant human interleukin-1 beta (IL-1). METHODS The direct isolation of messenger RNA (mRNA) from articular cartilage without the prior isolation of chondrocytes is described. The in vivo expression of stromelysin was examined at the mRNA level by Northern blot analysis, and at the protein level by in situ… CONTINUE READING
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