In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I.

@article{Nicolau1983InVE,
  title={In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I.},
  author={Cristina Nicolau and Alain le Pape and Philippe Soriano and Françoise Fargette and Marc Juhel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 4},
  pages={
          1068-72
        }
}
A recombinant plasmid encoding rat preproinsulin I was encapsulated in large liposomes and intravenously injected in rats. Glycemia and blood, splenic, and hepatic insulin were assayed at various times beginning 6 hr after inoculation. The results were compared with controls that had received (i) empty liposomes, (ii) liposomes carrying the Escherichia coli pBR322 plasmid, (iii) the free rat insulin I gene, and (iv) no injection at all. Whereas all controls showed unchanged glucose and insulin… CONTINUE READING
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