In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

@inproceedings{Faideau2010InVE,
  title={In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects},
  author={Mathilde Faideau and Jinho Jay Kim and Kerry A. Cormier and Richard Gilmore and Mackenzie Welch and Gwennaelle Auregan and Noelle Dufour and Martine Guillermier and Emmanuel Brouillet and Philippe Hantraye and Nicole D{\'e}glon and Robert Ferrante and Gilles Bonvento},
  booktitle={Human molecular genetics},
  year={2010}
}
Huntington's disease (HD) is a neurodegenerative disorder previously thought to be of primary neuronal origin, despite ubiquitous expression of mutant huntingtin (mHtt). We tested the hypothesis that mHtt expressed in astrocytes may contribute to the pathogenesis of HD. To better understand the contribution of astrocytes in HD in vivo, we developed a novel mouse model using lentiviral vectors that results in selective expression of mHtt into striatal astrocytes. Astrocytes expressing mHtt… CONTINUE READING

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