In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey

@inproceedings{Wei2014InVE,
  title={In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey},
  author={Fuxin Wei and Rui Lin Zhong and Zhiyu Zhou and Le Wang and Ximin Pan and Shangbin Cui and Xuenong Zou and Manman Gao and Haixing Sun and Wenfang Chen and Shao-Yu Liu},
  booktitle={BMC musculoskeletal disorders},
  year={2014}
}
BACKGROUND Recently, biological therapies for early intervention of degenerative disc disease have been introduced and developed; however, a functional animal model that mimics slowly progressive disc degeneration of humans does not exist. The objective of this study was to establish a slowly progressive and reproducible intervertebral disc (IVD) degeneration model. METHODS The subchondral bone adjacent to the lumbar IVDs (L3/4 and L5/6) of ten rhesus monkeys was randomly injected with 4 ml… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

  • JA Hoyland, C Le Maitre, AJ Freemont
  • Rheumatology (Oxford)
  • 2008
Highly Influential
12 Excerpts

Similar Papers

Loading similar papers…