In vivo experimental evidence that the nitric oxide pathway is involved in the X-ray-induced antiangiogenicity.

@article{Hatjikondi1996InVE,
  title={In vivo experimental evidence that the nitric oxide pathway is involved in the X-ray-induced antiangiogenicity.},
  author={O. Hatjikondi and Panagiota Ravazoula and Dimitris Kardamakis and Johannes C.A. Dimopoulos and Stamatis Papaioannou},
  journal={British Journal of Cancer},
  year={1996},
  volume={74},
  pages={1916 - 1923}
}
We have investigated both the effects of X-rays on angiogenesis and the possible role of nitric oxide (NO) on the observed antiangiogenic effect of X-rays, using as an in vivo model the chick embryo chorioallantoic membrane (CAM). These effects were assessed both morphologically and biochemically, by measuring vascular density and collagenous protein biosynthesis, respectively, on days 9 and 14 of the chick embryo development. Vascular density and cytotoxicity of the CAM were also evaluated… CONTINUE READING

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