In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse.

@article{Kawabata2001InVE,
  title={In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse.},
  author={Atsufumi Kawabata and Ryotaro Kuroda and Nobuyuki Nagata and Naoyuki Kawao and Takashi Masuko and Hiroyuki Nishikawa and Kenzo Kawai},
  journal={British journal of pharmacology},
  year={2001},
  volume={133 8},
  pages={1213-8}
}
1. Protease-activated receptors (PARs) 1 and 2 modulate the gastric and intestinal smooth muscle motility in vitro. In the present study, we examined if activation of PAR-2 and PAR-1 could alter gastrointestinal transit in mice. 2. Intraperitoneal administration of the PAR-2-activating peptide SLIGRL-NH(2), but not the inactive control LSIGRL-NH(2), at 1 - 5 micromol kg(-1), in combination with the aminopeptidase inhibitor amastatin at 2.5 micromol kg(-1), facilitated gastrointestinal transit… CONTINUE READING

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