In vivo evidence that erythropoietin protects neurons from ischemic damage.

@article{Sakanaka1998InVE,
  title={In vivo evidence that erythropoietin protects neurons from ischemic damage.},
  author={Masahiro Sakanaka and T C Wen and S Matsuda and Satohiro Masuda and Etsuo Morishita and Motoshi Nagao and Ryogen Sasaki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 8},
  pages={4635-40}
}
Erythropoietin (EPO) produced by the kidney and the liver (in fetuses) stimulates erythropoiesis. In the central nervous system, neurons express EPO receptor (EPOR) and astrocytes produce EPO. EPO has been shown to protect primary cultured neurons from N-methyl-D-aspartate (NMDA) receptor-mediated glutamate toxicity. Here we report in vivo evidence that EPO protects neurons against ischemia-induced cell death. Infusion of EPO into the lateral ventricles of gerbils prevented ischemia-induced… CONTINUE READING