In vivo evidence for the reversible action of the monoamine oxidase inhibitor brofaromine on 5-hydroxytryptamine release in rat brain

@article{Bel1995InVE,
  title={In vivo evidence for the reversible action of the monoamine oxidase inhibitor brofaromine on 5-hydroxytryptamine release in rat brain},
  author={N{\'u}ria Bel and Francesc Casa{\~n}as Artigas},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1995},
  volume={351},
  pages={475-482}
}
We have used intracerebral microdialysis to examine the reversibility of the action of brofaromine, a selective inhibitor of monoamine oxidase-A (MAO, E.C. 1.4.3.4.), on 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) output in rat frontal cortex. Brofaromine significantly increased the 5-HT output to about 200% of basal values 4 h after the s.c. administration of 10 and 30 mg/kg (but not 3 mg/kg) and reduced the concentration of 5-HIAA in the dialysate dose-dependently (61… CONTINUE READING
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Effects of local and systemic MAO inhibitors on extracellular brain 5-hydroxytryptamine and 5hydroxyindoleacetic acid in the frontal cortex and raphe nuclei of freely moving rats

  • P Celada, F Artigas
  • An in vivo microdialysis study…
  • 1993

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