In vivo evidence for the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli.

@article{Xia1995InVE,
  title={In vivo evidence for the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli.},
  author={Weiya Xia and William Dowhan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 3},
  pages={
          783-7
        }
}
In vitro, anionic phospholipids can reactivate inactivated DnaA protein, which is essential for initiation of DNA replication at the oriC site of Escherichia coli [Sekimizu, K. & Kornberg, A. (1988) J. Biol. Chem. 263, 7131-7135]. Mutations in the pgsA gene (encoding phosphatidylglycerophosphate synthase) limit the synthesis of the major anionic phospholipids and lead to arrest of cell growth. We report herein that a mutation in the rnhA gene (encoding RNase H) that bypasses the need for the… CONTINUE READING
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