In vivo evidence for the efflux transport of pentazocine from the brain across the blood–brain barrier using the brain efflux index method

@article{Moriki2005InVE,
  title={In vivo evidence for the efflux transport of pentazocine from the brain across the blood–brain barrier using the brain efflux index method},
  author={Yoshiaki Moriki and Toyofumi Suzuki and Takayuki Furuishi and Toshiro Fukami and Kazuo Tomono and Jun Watanabe},
  journal={Journal of Drug Targeting},
  year={2005},
  volume={13},
  pages={53 - 59}
}
  • Yoshiaki Moriki, Toyofumi Suzuki, +3 authors Jun Watanabe
  • Published 2005
  • Chemistry, Medicine
  • Journal of Drug Targeting
  • The efflux transport of pentazocine (PTZ) from the brain across the blood–brain barrier (BBB) was investigated using the Brain Efflux Index method. PTZ was eliminated with the apparent elimination half-life of 13.0 min after microinjection into the parietal cortex area 2 region of the rat brain. The apparent efflux clearance of PTZ across the BBB was 137 μl/min/g brain, which was calculated from the elimination rate constant (5.35 × 10−2 min−1) and the distribution volume in the brain (2.56 ml… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-8 OF 8 CITATIONS

    Blood-brain barrier transport of naloxone does not involve P-glycoprotein-mediated efflux.

    VIEW 6 EXCERPTS
    CITES METHODS & BACKGROUND

    Challenges for blood–brain barrier (BBB) screening

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    Brainpeps: the blood–brain barrier peptide database

    VIEW 2 EXCERPTS
    CITES METHODS & BACKGROUND

    [Blood-brain barrier transport of opioid analgesics].

    • Toyofumi Suzuki
    • Chemistry, Medicine
    • Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
    • 2011

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 35 REFERENCES

    Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier.

    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL

    P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.

    VIEW 6 EXCERPTS
    HIGHLY INFLUENTIAL

    Rat Organic Anion Transporter 3 (rOAT3) is Responsible for Brain-to-Blood Efflux of Homovanillic Acid at the Abluminal Membrane of Brain Capillary Endothelial Cells

    VIEW 2 EXCERPTS