In vivo evidence for possible up-regulating roles of lysophosphatidic acid around fertilization in rats

@inproceedings{Takeda2018InVE,
  title={In vivo evidence for possible up-regulating roles of lysophosphatidic acid around fertilization in rats},
  author={Tae Takeda and Miki Shirasaka and Makoto Sugiyama and Ryota Terashima and Mitsumori Kawaminami and Shiro Kurusu},
  booktitle={The Journal of veterinary medical science},
  year={2018}
}
Lysophosphatidic acid (LPA) produced by autotaxin (ATX) is recognized as a multi-functional mediator in mammalian reproduction. This study focused on possible effect(s) of LPA on ovulated cumulus-oocyte complexes (COCs) around fertilization in rats in vivo. Immunohistochemistry revealed the cell-type-dependent localization of candidates of synthetic enzymes, ATX and two phospholipases A2 isofroms, and LPA receptors LPA1-4 in ovulated COCs and in oviductal epithelium. The eggs ovulated with a… CONTINUE READING
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