In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia.

@article{Pickkers2006InVE,
  title={In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia.},
  author={Peter Pickkers and Mirrin Josefien Dorresteijn and Martijn P. W. J. M. Bouw and Johannes G. van der Hoeven and P. G. F. M. Smits},
  journal={Circulation},
  year={2006},
  volume={114 5},
  pages={414-21}
}
BACKGROUND During septic shock, the vasoconstrictor response to norepinephrine is seriously blunted. Animal experiments suggest that hyperpolarization of smooth muscle cells by opening of potassium (K) channels underlies this phenomenon. In the present study, we examined whether K-channel blockers and/or nitric oxide (NO) synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia. METHODS AND RESULTS Volunteers received 2 ng/kg Escherichia coli… CONTINUE READING

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Activation of the ATP-dependent potassium channel attenuates norepinephrine-induced vasoconstriction in the human forearm

P Pickkers, AJ Jansen Van Rosendaal, JG van der Hoeven, P. Smits
Shock • 2004

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