In vivo evidence for increased apolipoprotein A-I catabolism in subjects with impaired glucose tolerance.

@article{Pietzsch1998InVE,
  title={In vivo evidence for increased apolipoprotein A-I catabolism in subjects with impaired glucose tolerance.},
  author={Jens Pietzsch and U. Julius and Stefan Nitzsche and Markolf Hanefeld},
  journal={Diabetes},
  year={1998},
  volume={47 12},
  pages={1928-34}
}
The in vivo kinetics of the HDL apolipoproteins (apo) A-I and A-II were studied in six subjects with impaired glucose tolerance (IGT) and six control subjects with normal glucose tolerance (NGT), using a stable isotope approach. During a 12-h primed constant infusion of L-[ring-13C6]-phenylalanine, tracer enrichment was determined in apoA-I and apoA-II from ultracentrifugally isolated HDL. The rates of HDL apoA-I and apoA-II production and catabolism were estimated using a one-compartment model… CONTINUE READING

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