In vivo evidence for a prodrug activation mechanism during colibactin maturation.

Abstract

Releasing the cytopath: We have identified an N-myristoyl-D-asparagine (1) as the free N-terminal prodrug scaffold in cytopathogenic Escherichia coli strains expressing the colibactin gene cluster. Colibactin is released in vivo upon cleavage of precolibactin. We provide for the first time in vivo evidence of the prodrug-like release mechanism of colibactin.

DOI: 10.1002/cbic.201300208
020406020132014201520162017
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@article{Bian2013InVE, title={In vivo evidence for a prodrug activation mechanism during colibactin maturation.}, author={Xiaoying Bian and Jun Fu and Alberto Plaza and Jennifer Herrmann and Dominik Pistorius and A. Francis Stewart and Youming Zhang and Rolf K. Mueller}, journal={Chembiochem : a European journal of chemical biology}, year={2013}, volume={14 10}, pages={1194-7} }