In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

@article{Ksters1997InVE,
  title={In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis},
  author={Sabine K{\"u}sters and Gisa Tiegs and Lena Alexopoulou and Manolis Pasparakis and Eleni Douni and Gerald K{\"u}nstle and Horst Bluethmann and A. Wendel and Klaus Pfizenmaier and George Kollias and Matthias Grell},
  journal={European Journal of Immunology},
  year={1997},
  volume={27}
}
  • Sabine Küsters, Gisa Tiegs, +8 authors Matthias Grell
  • Published 1997
  • Biology, Medicine
  • European Journal of Immunology
The significance of tumor necrosis factor receptor 1 (TNFR1) for TNF function in vivo is well documented, whereas the role of TNFR2 so far remains obscure. In a model of concanavalin A (Con A)‐induced, CD4+ T cell‐dependent experimental hepatitis in mice, in which TNF is a central mediator of apoptotic and necrotic liver damage, we now provide evidence for an essential in vivo function of TNFR2 in this pathophysiological process. We demonstrate that a cooperation of TNFR1 and TNFR2 is required… Expand
TNF-α-Induced Expression of Adhesion Molecules in the Liver Is Under the Control of TNFR1—Relevance for Concanavalin A-Induced Hepatitis1
  • D. Wolf, Rupert Hallmann, +5 authors Gisa Tiegs
  • Biology, Medicine
  • The Journal of Immunology
  • 2001
Parenchymal, But Not Leukocyte, TNF Receptor 2 Mediates T Cell-Dependent Hepatitis in Mice 1
Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand.
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