In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia.

@article{Esterlis2014InVE,
  title={In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia.},
  author={I. Esterlis and Mohini Ranganathan and F. Bois and Brian P. Pittman and Marina R. Picciotto and Lara Shearer and Alan Anticevic and Jon Brandon Carlson and Mark J. Niciu and Kelly P. Cosgrove and Deepak Cyril D'souza},
  journal={Biological psychiatry},
  year={2014},
  volume={76 6},
  pages={495-502}
}
BACKGROUND Schizophrenia is associated with very high rates of tobacco smoking. The latter may be related to an attempt to self-medicate symptoms and/or to alterations in function of high-affinity β2-subunit-containing nicotinic acetylcholine receptors (β2*-nAChRs). METHODS Smoking and nonsmoking subjects with schizophrenia (n=31) and age-, smoking-, and sex-matched comparison subjects (n=31) participated in one [123I]5-IA-85380 single photon emission computed tomography scan to quantify β2… CONTINUE READING
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