In vivo evidence against clomethiazole being neuroprotective against MDMA (‘ecstasy’)-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism

@article{Colado1999InVE,
  title={In vivo evidence against clomethiazole being neuroprotective against MDMA (‘ecstasy’)-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism},
  author={Mar{\'i}a Isabel Colado and Esther O’shea and B Esteban and R. Granados and Alfred Richard Green},
  journal={Neuropharmacology},
  year={1999},
  volume={38},
  pages={307-314}
}
  • María Isabel Colado, Esther O’shea, +2 authors Alfred Richard Green
  • Published in Neuropharmacology 1999
  • Chemistry, Medicine
  • Clomethiazole is an effective neuroprotective agent against the degeneration of 5-HT neurones that follows administration of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy'). Since there is good evidence that free radical formation resulting from auto-oxidation of MDMA metabolites is responsible for the degeneration we have examined whether clomethiazole is a free radical scavenger. MDMA (15 mg/kg i.p.) increased the formation of 2,3- and 2,5-dihydroxybenzoic acids (2,3-DHBA and 2,5-DHBA… CONTINUE READING

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