In vivo evaluation of two new sustained release formulations elaborated by one-step melt granulation: level A in vitro-in vivo correlation.

@article{Ochoa2010InVE,
  title={In vivo evaluation of two new sustained release formulations elaborated by one-step melt granulation: level A in vitro-in vivo correlation.},
  author={Lourdes Ochoa and Manoli Igartua and Rosa Maria Hern{\'a}ndez and Mar{\'i}a {\'A}ngeles Solin{\'i}s and Alicia Rodr{\'i}guez Gasc{\'o}n and Jos{\'e} luis Pedraz},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2010},
  volume={75 2},
  pages={232-7}
}
The objective of this study was to evaluate in vivo two sustained release formulations elaborated by a one-step melt granulation method using theophylline as model drug. Both formulations presented differences in the in vitro release profile due to the hydrophilic or lipophilic nature of the binder employed (PEG 6000 or glycerol monostearate). The formulations were administered to Beagle dogs, and plasma levels were compared. Both formulations provided a sustained plasma concentration profile… CONTINUE READING