In vivo evaluation of tablets and capsules containing spray-dried o/w-emulsions for oral delivery of poorly soluble drugs.

@article{Hansen2005InVE,
  title={In vivo evaluation of tablets and capsules containing spray-dried o/w-emulsions for oral delivery of poorly soluble drugs.},
  author={Tue Hansen and Per Gunnar Holm and Morten Rohde and Kirsten Schultz},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={293 1-2},
  pages={203-11}
}
It is recognised that poorly soluble drugs may show an increased oral bioavailability when incorporated in o/w-emulsions. Encapsulating the emulsion lipid droplets in hydroxypropyl methylcellulose (HPMC) by spray drying has been demonstrated to preserve an improved bioavailability releasing lipid droplets from the powder in vivo. However, the spray-dried powder is cohesive and bulky requiring additional processing to improve handling. This was resolved in previous work where a directly… CONTINUE READING
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