In vivo evaluation of substituted 3-amino-1,4-benzodiazepines as anti-depressant, anxiolytic and anti-nociceptive agents.

@article{Lattmann2009InVE,
  title={In vivo evaluation of substituted 3-amino-1,4-benzodiazepines as anti-depressant, anxiolytic and anti-nociceptive agents.},
  author={Eric Lattmann and Pornthip Lattmann and Yodchai Boonprakob and Wanchai Airarat and Harjit Singh and Michael Offel and Jintana Sattayasai},
  journal={Arzneimittel-Forschung},
  year={2009},
  volume={59 2},
  pages={61-71}
}
Oxazepam (CAS 604-75-1) 4a served as building block in the synthesis of substituted 3-amino-1,4-benzodiazepines, which were subsequently tested in various CNS animal models. The hydroxy group of oxazepam was either activated as a chloride (Method A) or as a phosphor-oxy derivative (Method B) giving the desired 3-amino-1,4-benzodiapines 6a-6r in high yields… CONTINUE READING