In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice.

@article{Tanaka2010InVE,
  title={In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice.},
  author={Takemi Tanaka and Biana Godin and Rohan C. Bhavane and Ren{\'e} Nieves-Alicea and Jian-ren Gu and Xiaohong Liu and Ciro Chiappini and Jean Raymond Garcia Fakhoury and Sarah Amra and Alfred Ewing and Qijun Li and Isaiah Josh Fidler and Mauro Ferrari},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={402 1-2},
  pages={
          190-7
        }
}
Porous silicon (pSi) is being extensively studied as an emerging material for use in biomedical applications, including drug delivery, based on the biodegradability and versatile chemical and biophysical properties. We have recently introduced multistage nanoporous silicon microparticles (S1MP) designed as a cargo for nanocarrier drug delivery to enable the loaded therapeutics and diagnostics to sequentially overcome the biological barriers in order to reach their target. In this first report… CONTINUE READING
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