In vivo evaluation of limonene-based transdermal therapeutic system of nicorandil in healthy human volunteers.

Abstract

Hydroxypropyl methylcellulose (HPMC) gel drug reservoir system prepared with 70:30 v/v ethanol-water solvent system containing 6% w/w of limonene was effective in promoting the in vitro transdermal delivery of nicorandil. The objective of the present study was to fabricate and evaluate a limonene-based transdermal therapeutic system (TTS) for its ability to… (More)

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@article{Krishnaiah2005InVE, title={In vivo evaluation of limonene-based transdermal therapeutic system of nicorandil in healthy human volunteers.}, author={Yellela S. R. Krishnaiah and Devaraj V Chandrasekhar and Bukurie Rama and B. Jayaram and V. Satyanarayana and Saleh M. Al-Saidan}, journal={Skin pharmacology and physiology}, year={2005}, volume={18 6}, pages={263-72} }