In vivo evaluation of an 111In-labeled ST-peptide analog for specific-targeting of human colon cancers.

@article{Gali2001InVE,
  title={In vivo evaluation of an 111In-labeled ST-peptide analog for specific-targeting of human colon cancers.},
  author={Hariprasad Gali and Gary L. Sieckman and Timothy J. Hoffman and Nellie K. Owen and Derek T. Chin and Leonard Ralph Forte and Wynn A. Volkert},
  journal={Nuclear medicine and biology},
  year={2001},
  volume={28 8},
  pages={903-9}
}
In vitro competitive binding studies of In-DOTA-NCS-6-Ahx-Phe(19)-ST[1-19] vs. 125I-Tyr(5)-6-Ahx-Phe(19)-ST[1-19] with guanylate cyclase -C (GC-C) receptors on human colon cancer LS-180 cells revealed an IC(50) value of 7.7 +/- 0.1.6 nM. The in vitro cellular residualization studies of the 111In-DOTA-NCS-ST peptide and GC-C receptor mediated stimulated cGMP… CONTINUE READING