In vivo evaluation of MMP sensitive high-molecular weight HA-based hydrogels for bone tissue engineering.

@article{Kim2010InVE,
  title={In vivo evaluation of MMP sensitive high-molecular weight HA-based hydrogels for bone tissue engineering.},
  author={Jungju Kim and In Sook Kim and Tae Hyung Cho and Ho Chul Kim and So jeong Yoon and Jaesoon Choi and Yongdoo Park and Kyung Sun and Soon Jung Hwang},
  journal={Journal of biomedical materials research. Part A},
  year={2010},
  volume={95 3},
  pages={
          673-81
        }
}
Hyaluronic acid (170 kDa)-based hydrogel was synthesized using acrylated hyaluronic acid (HA) and matrix metalloproteinase (MMP) sensitive HA-based hydrogels were then prepared by conjugation with two different peptides: cell adhesion peptides containing integrin-binding domains (Arg-Gly-Asp: RGD) and a cross-linker with MMP degradable peptides to mimic the remodeling characteristics of natural extracellular matrices by cell-derived MMPs. Mechanical properties of these hydrogels were evaluated… CONTINUE READING

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