In vivo evaluation of MMP sensitive high-molecular weight HA-based hydrogels for bone tissue engineering.

@article{Kim2010InVE,
  title={In vivo evaluation of MMP sensitive high-molecular weight HA-based hydrogels for bone tissue engineering.},
  author={J. Kim and I. Kim and T. H. Cho and H. C. Kim and So Jeong Yoon and Jaesoon Choi and Y. Park and K. Sun and S. J. Hwang},
  journal={Journal of biomedical materials research. Part A},
  year={2010},
  volume={95 3},
  pages={
          673-81
        }
}
  • J. Kim, I. Kim, +6 authors S. J. Hwang
  • Published 2010
  • Materials Science, Medicine
  • Journal of biomedical materials research. Part A
  • Hyaluronic acid (170 kDa)-based hydrogel was synthesized using acrylated hyaluronic acid (HA) and matrix metalloproteinase (MMP) sensitive HA-based hydrogels were then prepared by conjugation with two different peptides: cell adhesion peptides containing integrin-binding domains (Arg-Gly-Asp: RGD) and a cross-linker with MMP degradable peptides to mimic the remodeling characteristics of natural extracellular matrices by cell-derived MMPs. Mechanical properties of these hydrogels were evaluated… CONTINUE READING
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