In vivo evaluation of Kumazasa extract and chitosan films containing the extract against deep skin ulcer model in rats.

@article{Hirose2007InVE,
  title={In vivo evaluation of Kumazasa extract and chitosan films containing the extract against deep skin ulcer model in rats.},
  author={Kaori Hirose and Hiraku Onishi and Masanaho Sasatsu and Kazuo Takeshita and Kazuto Kouzuma and Koichi Isowa and Yoshiharu Machida},
  journal={Biological \& pharmaceutical bulletin},
  year={2007},
  volume={30 12},
  pages={
          2406-11
        }
}
Kumazasa extract (KE) and its whole solid component (EXT)-containing chitosan films produced by drying in air and lyophilization, abbreviated to ND and FD films, respectively, were examined for efficacy and healing features using a deep skin ulcer model in rats. Their effects were compared with those of clinically available dosage forms, Beschitin W, Geben cream and U-PASTA. KE alone exhibited a better effect as compared with other preparations, and FD films also more effective than control in… Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Histo-chemical studies on the anti-ulcer effect of bamboo grass in rats.
TLDR
Results suggest that a microscopic haemostatic effect of Folin reinforced by a membrane-stabilizing effect might be responsible for the prevention of the gastric lesions. Expand
Formulation design of ointment base suitable for healing of lesions in treatment of bedsores.
TLDR
The curd tension meter tests for the ointments prepared with the various polymers showed that the MO-HPC base, which showed the highest sustained drug releasing property, was found to have the highest hardness, which means that HPC formulated into the base forms the most rigid gel structure to resist the erosion of the Ointment and to control the drug release. Expand
Chitosan-alginate PEC membrane as a wound dressing: Assessment of incisional wound healing.
TLDR
On the basis of its biocompatibility and wound-healing efficacy, the chitosan-alginate PEC membrane can be considered for wound-dressing applications. Expand
Potential applications of chitosan in veterinary medicine.
TLDR
The veterinary drug delivery areas most likely to benefit from chitosan are the delivery of chemotherapeutics such as antibiotics, antiparasitics, anaesthetics, painkillers and growth promotants to mucosal epithelium for absorption for local or systemic activity, and the Delivery of immunomodulatory agents to the mucosal associated lymphoid tissue for induction or modulation of local immune responses. Expand
Evaluation of antibiotic-loaded collagen-hyaluronic acid matrix as a skin substitute.
TLDR
Though the tobramycin incorporated matrix containing basic fibroblast growth factor or platelet-derived growth factor significantly enhanced wound healing, the potential efficacy of crosslinked collagen-HA matrix containing antibiotics and growth factors for defective skin tissue replacement and infection prevention is demonstrated. Expand
Hyaluronic acid and silver sulfadiazine-impregnated polyurethane foams for wound dressing application
  • Y. Cho, J. Lee, +5 authors H. J. Kim
  • Materials Science, Medicine
  • Journal of materials science. Materials in medicine
  • 2002
TLDR
From the drug release and fibroblast adhesion studies, it was observed that PU foam impregnated with both HA and AgSD shows good drug release behavior and low adhesion of the cells. Expand
Development of a new wound dressing with antimicrobial delivery capability
  • Y. Kuroyanagi, A. Shiraishi, +4 authors N. Shioya
  • Medicine
  • Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 1994
TLDR
This work has developed a biosynthetic wound dressing with a drug delivery capability that is capable of suppressing bacterial growth and minimizing cellular damage in the treatment of wounds inflicted on rats and rabbits and was evaluated in a nonrandomized open‐label study of 31 clinical cases. Expand
Comparison of Silver Sulfadiazine, Povidone‐Iodine and Physiologic Saline in the Treatment of Chronic Pressure Ulcers
TLDR
In 100 percent of the ulcers treated with silver sulfadiazine cream the bacterial counts were reduced to 105 or less per gram of tissue within the three‐week test period, compared to 78.6 percent in those treated with saline and 63.6% in those treating with povidone‐iodine solution. Expand
Immunological activity of chitin and its derivatives.
The effect of chitin and its derivatives on the activation of peritoneal macrophages in vivo, on the suppression of tumour growth in syngeneic mice and on the protection of the host against bacterialExpand
Effects of Sasa Health, extract of bamboo grass leaves, on spontaneous mammary tumourigenesis in SHN mice.
TLDR
Findings indicate that Sasa Health could be a promising agent for the protection and therapy of breast and other types of tumours. Expand
...
1
2
3
...