In vivo evaluation of 99mTc/188Re-labeled linear alpha-melanocyte stimulating hormone analogs for specific melanoma targeting.

@article{Chen1999InVE,
  title={In vivo evaluation of 99mTc/188Re-labeled linear alpha-melanocyte stimulating hormone analogs for specific melanoma targeting.},
  author={J Chen and Michael F. Giblin and N. Wang and Silvia S. Jurisson and Thomas P. Quinn},
  journal={Nuclear medicine and biology},
  year={1999},
  volume={26 6},
  pages={
          687-93
        }
}
Melanoma-targeting properties of (99m)technetium-labeled cyclic alpha-melanocyte-stimulating hormone peptide analogues.
TLDR
The compact cyclic structure of 99mTc-CCMSH, its resistance to degradation, and its enhanced intracellular retention are the major contributing factors to the superior in vivo tumor targeting properties of 99tc- CCMSH.
Melanoma targeting with [99mTc(N)(PNP3)]-labeled α-melanocyte stimulating hormone peptide analogs: Effects of cyclization on the radiopharmaceutical properties.
Design and evaluation of new Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptides for melanoma imaging.
TLDR
Overall, high melanoma uptake coupled with fast urinary clearance of (99m)Tc(EDDA)-HYNIC-GGNle-CycMSH(hex) highlighted its potential for metastatic melanoma detection in the future.
Radiochemical and radiopharmacological characterization of a 64 Cu-labeled α-MSH analog conjugated with different chelators.
TLDR
The three 64 Cu-labeled conjugates exhibited high binding affinity (low nanomolar range) in murine B16F10, human MeWo, and human TXM13 cells, and should be considered for further in vivo investigations using a suitable xenograft mouse model.
Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties.
  • J. Chen, Z. Cheng, T. Quinn
  • Chemistry, Biology
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2001
TLDR
The novel ReO-coordinated cyclic structure of DOTA-Re CCMSH contributes significantly to its enhanced tumor-targeting and renal clearance properties and makes DOTAReCCMSH an excellent candidate for melanoma radiodetection and radiotherapy.
Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma.
Targeted melanoma imaging and therapy with radiolabeled alpha-melanocyte stimulating hormone peptide analogues.
  • T. Quinn, X. Zhang, Y. Miao
  • Biology, Chemistry
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
  • 2010
TLDR
Strong pre-clinical imaging and therapy data highlight the clinical potential use of radiolabeled a-MSH peptides for melanoma imaging and treatment of disseminated disease.
Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator.
TLDR
The data suggest the superior stability of the (64)Cu-CBTE2A moiety compared with (64]Cu-DOTA, making ( 64) Cu-CB TE2A-ReCCMSH(Arg(11)) an ideal candidate for the PET of malignant melanoma.
New small 99mTc-labeled peptides for HER2 receptor imaging.
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