In vivo evaluation of 188Re‐labeled alpha‐melanocyte stimulating hormone peptide analogs for melanoma therapy

@article{Miao2002InVE,
  title={In vivo evaluation of 188Re‐labeled alpha‐melanocyte stimulating hormone peptide analogs for melanoma therapy},
  author={Y. Miao and N. Owen and D. Whitener and F. Gallazzi and T. Hoffman and T. Quinn},
  journal={International Journal of Cancer},
  year={2002},
  volume={101}
}
The purpose of our study was to optimize melanoma tumor uptake of 188Re‐CCMSH and reduce its nonspecific kidney retention. Nephrotoxicity is often a serious problem associated with targeted radiotherapy, therefore, increasing the tumor/kidney uptake ratio of 188Re‐CCMSH is crucial for optimizing its therapeutic efficacy. Structural modification of the peptide and amino acid co‐infusion were investigated as strategies to improve the tumor/kidney uptake ratio of 188Re‐CCMSH. The substitution of… Expand
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