In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia.

@article{Marrazzo2006InVE,
  title={In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia.},
  author={Agostino Marrazzo and Carmela Parenti and Valentina Scavo and Simone Ronsisvalle and Giovanna Maria Scoto and Giuseppe Ronsisvalle},
  journal={Life sciences},
  year={2006},
  volume={78 21},
  pages={2449-53}
}
The compound (+)-MR200 [(+)-methyl (1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate] is a sigma ligand with increased affinity and selectivity compared to the structurally related ligand haloperidol. From the results of a previous study on the modulation of a systemically injected KOP opioid agonist analgesia by (+)-MR200, we analysed the influence of this sigma ligand on the antinociceptive effect of centrally injected MOP, DOP, and KOP selective… CONTINUE READING