In vivo estrogen manipulations on coronary capillary network and angiogenic molecule expression in middle-aged female rats.

@article{Jesmin2002InVE,
  title={In vivo estrogen manipulations on coronary capillary network and angiogenic molecule expression in middle-aged female rats.},
  author={Subrina Jesmin and Ichiro Sakuma and Yuichi Hattori and Akira Kitabatake},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2002},
  volume={22 10},
  pages={1591-7}
}
OBJECTIVE Estrogen replacement therapy (ERT) ameliorates symptoms in postmenopausal women with syndrome X. We hypothesized that estrogen deprivation and replacement may modulate coronary expressions of angiogenic molecules, thereby modifying the coronary capillary network in perimenopausal women. METHODS AND RESULTS Middle-aged (40-week-old) female rats were subjected to sham surgery, ovariectomy, or ovariectomy with ERT. Using immunohistochemical and in situ hybridization techniques, we… CONTINUE READING
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Estrogen receptor : a new dimension in estrogen mechanism of action

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