In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.

@article{Kim1997InVE,
  title={In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.},
  author={Jung-whan Kim and Velpandi Ayyavoo and Mark L. Bagarazzi and Michael Chattergoon and Kesen Dang and Bingxiang Wang and Jean D. Boyer and David B. Weiner},
  journal={Journal of immunology},
  year={1997},
  volume={158 2},
  pages={816-26}
}
Recent studies support the importance of investigating a DNA vaccination approach for the immunologic control of HIV-1. In this regard, it may be important to specifically engineer immune responses in order to improve on first generation vaccine attempts. Especially for HIV, induction of cell-mediated immunity may be an important feature for any candidate vaccine. In an attempt to engineer in vivo the enhancement of cellular immune response and to direct Ag-dependent immune response from Th2 to… CONTINUE READING