In vivo endoscopic optical biopsy with optical coherence tomography.

@article{Tearney1997InVE,
  title={In vivo endoscopic optical biopsy with optical coherence tomography.},
  author={Guillermo J. Tearney and Mark E. Brezinski and Brett E. Bouma and Stephen Ao Boppart and Costas Pitris and James F. Southern and James G. Fujimoto},
  journal={Science},
  year={1997},
  volume={276 5321},
  pages={
          2037-9
        }
}
Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1… 
Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography.
TLDR
The ability of ultrahigh resolution endoscopic OCT to image tissue morphology at an unprecedented resolution in vivo advances the development of OCT as a potential imaging tool for the early detection of neoplastic changes in biological tissue.
Diagnosis of Biological Tissue Morphology and Function with Endoscopic Optical Coherence Tomography
TLDR
To test the endoscopic OCT system for imaging diagnosis of early epithelial cancers, rat bladder cancer models were used and the results show over 90% sensitivity and specificity.
Imaging needle for optical coherence tomography.
We describe a miniature optical coherence tomography (OCT) imaging needle that can be inserted into solid tissues and organs to permit interstitial imaging of their internal microstructures with
Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy.
TLDR
OCT can be used where standard excisional biopsy is hazardous or impossible, to reduce sampling errors associated with excisionality, and to guide interventional procedures, and its potential biomedical and clinical applications are described.
Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract
TLDR
This in vivo demonstration suggests that resolutions and acquisition rates are sufficient for imaging the human gastrointestinal tract and OCT shows promise for high-resolution image-guidance during diagnostic and surgical procedures.
Endoscopic Optical Coherence Tomography for Clinical Gastroenterology
TLDR
An overview of the clinical utility of endoscopic OCT in the gastrointestinal tract and of recent achievements using state-of-the-art endoscopic 3D-OCT imaging systems are provided.
Optical coherence tomography for ultrahigh resolution in vivo imaging
TLDR
Optical coherence tomography functions as a type of 'optical biopsy' to provide cross-sectional images of tissue structure on the micron scale and is a promising imaging technology because it can provide images of tissues in situ and in real time, without the need for excision and processing of specimens.
Optical Biopsy with Optical Coherence Tomography a
TLDR
The feasibility of OCT for optical biopsy was confirmed with in vitro tissue from the skeletal and male reproductive systems, supporting the hypothesis that OCT is an attractive technology for in vivo opticalBiopsy.
In-situ visualization and evaluation of neoplastic lesions of the human gastrointestinal tract using endoscopic optical coherence tomography
TLDR
Preliminary data indicate the potential of EOCT for routine clinical diagnostics in GI tissues, including early cancer detection and staging and detection of tumor margins.
...
...

References

SHOWING 1-10 OF 25 REFERENCES
Optical biopsy and imaging using optical coherence tomography
TLDR
Preliminary studies indicate the feasibility of developing OCT for a wide range of clinical and research diagnostic imaging applications, and the ability to non-excisionally evaluate tissue morphology using a catheter or an endoscope could have a significant impact on the diagnosis and management of a widerange of diseases.
Optical coherence tomography.
TLDR
Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
Rapid acquisition of in vivo biological images by use of optical coherence tomography.
TLDR
Dynamic, motion-artifact-free in vivo imaging of a beating Xenopus laevis (African frog) heart is demonstrated.
Subsurface imaging of living skin with optical coherence microscopy.
TLDR
The results of this study suggest that an optical coherence microscope may have value as a diagnostic tool for cases in which visualization of subcellular details is not required.
Optical coherence tomography of the human retina.
OBJECTIVE To demonstrate optical coherence tomography for high-resolution, noninvasive imaging of the human retina. Optical coherence tomography is a new imaging technique analogous to ultrasound B
In vivo retinal imaging by optical coherence tomography.
TLDR
These images represent the highest depth resolution in vivo retinal images to date and are to the authors' knowledge the first in vivo measurements of human retinal structure with optical coherence tomography.
Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography.
An all-solid-state Kerr-lens mode-locked Cr:forsterite laser operating at 1.28 microm is demonstrated as a shortcoherence-length, high-average-power source for optical coherence tomographic (OCT)
Dermatology
Exchange of protein molecules through connections between higher plant plastids.
TLDR
In transgenic plants in which the plastid stroma was labeled with green fluorescent protein (GFP), thin tubular projections emanated from individual plastids and sometimes connected to other plasts, which allow the exchange of molecules within an interplastid communication system, which may facilitate the coordination of plasts activities.
Barrett's esophagus. Natural history, incidence, etiology, and complications.
TLDR
The natural history of Barrett's esophagus is reviewed, the pathology and etiopathogenesis are considered in detail, as are the symptoms and complications of this condition.
...
...