In vivo endoscopic optical biopsy with optical coherence tomography.

  title={In vivo endoscopic optical biopsy with optical coherence tomography.},
  author={Guillermo J. Tearney and Mark E. Brezinski and Brett E. Bouma and Stephen Ao Boppart and Costas Pitris and James F. Southern and James G. Fujimoto},
  volume={276 5321},
Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1… 

Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography.

The ability of ultrahigh resolution endoscopic OCT to image tissue morphology at an unprecedented resolution in vivo advances the development of OCT as a potential imaging tool for the early detection of neoplastic changes in biological tissue.

Diagnosis of Biological Tissue Morphology and Function with Endoscopic Optical Coherence Tomography

To test the endoscopic OCT system for imaging diagnosis of early epithelial cancers, rat bladder cancer models were used and the results show over 90% sensitivity and specificity.

Imaging needle for optical coherence tomography.

We describe a miniature optical coherence tomography (OCT) imaging needle that can be inserted into solid tissues and organs to permit interstitial imaging of their internal microstructures with

Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy.

OCT can be used where standard excisional biopsy is hazardous or impossible, to reduce sampling errors associated with excisionality, and to guide interventional procedures, and its potential biomedical and clinical applications are described.

Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract

This in vivo demonstration suggests that resolutions and acquisition rates are sufficient for imaging the human gastrointestinal tract and OCT shows promise for high-resolution image-guidance during diagnostic and surgical procedures.

Optical coherence tomography

  • Zhongping Chen
  • Medicine, Physics
    OFC/NFOEC Technical Digest. Optical Fiber Communication Conference, 2005.
  • 2005
This chapter discusses clinical utilization of OCT via two functional developments: Doppler-based OCT for the quantification of particulate flow rates such as blood flow and optical coherence elastography for mapping of tissue mechanical properties.

In vivo optical coherence tomography: the role of the pathologist.

This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging and the role of the pathologist in interpreting high-resolution OCT images as a complement to standard tissue pathology.

Endoscopic Optical Coherence Tomography for Clinical Gastroenterology

An overview of the clinical utility of endoscopic OCT in the gastrointestinal tract and of recent achievements using state-of-the-art endoscopic 3D-OCT imaging systems are provided.

Optical coherence tomography for ultrahigh resolution in vivo imaging

Optical coherence tomography functions as a type of 'optical biopsy' to provide cross-sectional images of tissue structure on the micron scale and is a promising imaging technology because it can provide images of tissues in situ and in real time, without the need for excision and processing of specimens.



Optical biopsy and imaging using optical coherence tomography

Preliminary studies indicate the feasibility of developing OCT for a wide range of clinical and research diagnostic imaging applications, and the ability to non-excisionally evaluate tissue morphology using a catheter or an endoscope could have a significant impact on the diagnosis and management of a widerange of diseases.

Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology.

OCT represents a promising new technology for imaging vascular microstructure with a level of resolution not previously achieved with the use of other imaging modalities, and can be performed with a catheter integrated with a relatively inexpensive optical fiber.

Rapid acquisition of in vivo biological images by use of optical coherence tomography.

Dynamic, motion-artifact-free in vivo imaging of a beating Xenopus laevis (African frog) heart is demonstrated.

Subsurface imaging of living skin with optical coherence microscopy.

The results of this study suggest that an optical coherence microscope may have value as a diagnostic tool for cases in which visualization of subcellular details is not required.

Optical coherence tomography of the human retina.

OBJECTIVE To demonstrate optical coherence tomography for high-resolution, noninvasive imaging of the human retina. Optical coherence tomography is a new imaging technique analogous to ultrasound B

In vivo retinal imaging by optical coherence tomography.

These images represent the highest depth resolution in vivo retinal images to date and are to the authors' knowledge the first in vivo measurements of human retinal structure with optical coherence tomography.

Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering.

Evidence is given that suggests that certain features of microstructures embedded several hundred micrometres deep in a turbid tissue can still be detected and characterized and introduced a framework for understanding and quantifying beam-size effects by way of the mutual-coherence function.

Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography.

An all-solid-state Kerr-lens mode-locked Cr:forsterite laser operating at 1.28 microm is demonstrated as a shortcoherence-length, high-average-power source for optical coherence tomographic (OCT)