In vivo endoscopic optical biopsy with optical coherence tomography.

  title={In vivo endoscopic optical biopsy with optical coherence tomography.},
  author={Guillermo J. Tearney and Mark E. Brezinski and Brett E. Bouma and Stephen Ao Boppart and Costas Pitris and James F. Southern and James G. Fujimoto},
  volume={276 5321},
Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1… 
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