In vivo electroporation enhances the potency of poly-lactide co-glycolide (PLG) plasmid DNA immunization.

@article{Barbon2010InVE,
  title={In vivo electroporation enhances the potency of poly-lactide co-glycolide (PLG) plasmid DNA immunization.},
  author={Christine M Barbon and Lisa J Baker and Christa Lajoie and Urban Ramstedt and Mary Lynne Hedley and Thomas M Luby},
  journal={Vaccine},
  year={2010},
  volume={28 50},
  pages={7852-64}
}
Immunization with plasmid DNA that has been encapsulated in poly lactide-co-glycolide (PLG) microparticles targets the plasmid DNA to antigen presenting cells and elicits immune responses to the encoded antigen(s). Application of a series of electrical pulses (EPT) immediately following unformulated DNA injection enhances expression of the encoded antigen and increases immune responses. The combination of using EPT before or after PLG-encapsulated plasmid DNA immunization was tested to… CONTINUE READING