In vivo electrophysiological assessment of the agonistic properties of flibanserin at pre‐ and postsynaptic 5‐HT1A receptors in the rat brain

@article{Rueter1998InVE,
  title={In vivo electrophysiological assessment of the agonistic properties of flibanserin at pre‐ and postsynaptic 5‐HT1A receptors in the rat brain},
  author={Lynne E. Rueter and Claude de Montigny and Pierre U. Blier},
  journal={Synapse},
  year={1998},
  volume={29}
}
Flibanserin (BIMT 17) has been described as a 5‐HT1A agonist with preferential affinity for postsynaptic 5‐HT1A receptors and as a 5‐HT2A antagonist. Indeed, using the forskolin‐stimulated cAMP accumulation technique, flibanserin but not the 5‐HT1A agonists buspirone and 8‐OH‐DPAT had agonistic activity at postsynaptic 5‐HT1A receptors in the cerebral cortex. The present in vivo electrophysiological study investigated the agonistic properties of this novel compound in pre‐ and postsynaptic… 

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- HYDROXYTRYPTAMINE 1 A-LIKE RECEPTOR ACTIVATION IN THE ED NUCLEUS OF THE STRIA TERMINALIS : LECTROPHYSIOLOGICAL AND BEHAVIORAL

  • Biology
  • 2004
Data obtained from in vitro whole-cell patch clamp reording in the rat BNST slice show that exogenous application f 5-hydroxytryptamine (5-HT) evoked a heterogeneous reponse in BN STAL neurons, and fusion of 5-CT into the BnST significantly reduced the acousic startle response, without affecting the general motor activity.

5-hydroxytryptamine1A-like receptor activation in the bed nucleus of the stria terminalis: electrophysiological and behavioral studies.

It is proposed that in response to stressful stimuli, enhanced levels of 5-HT in the BNST AL plays a critical homeostatic role in feedback inhibition of the anxiogenic response to these stimuli.

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