In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model

Abstract

PURPOSE Histone deacetylase inhibitors are promising new substances in cancer therapy and have also been shown to sensitize different tumor cells to irradiation (XRT). We explored the effect as well as the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) in vivo in a malignant rhabdoid tumor (MRT) mouse model. METHODS AND MATERIAL… (More)
DOI: 10.1186/1748-717X-7-52

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@inproceedings{Thiemann2012InVE, title={In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model}, author={Markus Thiemann and Susanne Oertel and Volker Ehemann and Wilko Weichert and Albrecht Stenzinger and Marc Bischof and Klaus Josef Weber and Ram{\'o}n P{\'e}rez and Uwe Haberkorn and Andreas E. Kulozik and J{\"u}rgen Debus and P. Huber and Claudia Battmann}, booktitle={Radiation oncology}, year={2012} }