In vivo efficacy of oral and intraperitoneal administration of extracts of Warburgia ugandensis (Canellaceae) in experimental treatment of Old World cutaneous leishmaniasis caused by Leishmania major.

@article{Ngure2009InVE,
  title={In vivo efficacy of oral and intraperitoneal administration of extracts of Warburgia ugandensis (Canellaceae) in experimental treatment of Old World cutaneous leishmaniasis caused by Leishmania major.},
  author={P. Ngure and Z. Ng'ang'a and J. Ingonga and G. Rukunga and W. Tonui},
  journal={African journal of traditional, complementary, and alternative medicines : AJTCAM},
  year={2009},
  volume={6 2},
  pages={
          207-12
        }
}
  • P. Ngure, Z. Ng'ang'a, +2 authors W. Tonui
  • Published 2009
  • Medicine
  • African journal of traditional, complementary, and alternative medicines : AJTCAM
The antileishmanial activity of extracts of Warburgia ugandensis Spraque (Canellaceae), a known traditional therapy in Kenya was evaluated in vivo. Treatment of infected BALB/c mice with W. ugandensis extracts orally resulted in a reduction of the size of lesions compared to the untreated control. The lesion sizes differed significantly for the four extracts (p=0.039) compared to the untreated control. For mice treated by intraperitoneal injection, the lesion sizes increased initially for the… Expand
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