In vivo efficacy of glycopeptide-colistin combination therapies in a Galleria mellonella model of Acinetobacter baumannii infection.

@article{Hornsey2011InVE,
  title={In vivo efficacy of glycopeptide-colistin combination therapies in a Galleria mellonella model of Acinetobacter baumannii infection.},
  author={Michael Hornsey and David William Wareham},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 7},
  pages={3534-7}
}
The treatment of Acinetobacter baumannii infections poses a significant clinical challenge, with isolates resistant to all commonly used agents increasingly being reported. With few new agents in the pipeline, clinicians are increasingly turning to combinations of antimicrobials in the hope that they may act synergistically together. In this study we assessed the activities of two glycopeptide-colistin combinations both in vitro and using a Galleria mellonella caterpillar model of A. baumannii… CONTINUE READING
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, posting date . Whole - genome comparison of two Acinetobacter baumannii isolates from a single patient , where resistance developed during tigecycline therapy

  • G. Jander, L. G. Rahme, F. M. Ausubel
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