In-vivo efficacy of amodiaquine-artesunate in children with uncomplicated Plasmodium falciparum malaria in western Kenya.

@article{Thwing2009InvivoEO,
  title={In-vivo efficacy of amodiaquine-artesunate in children with uncomplicated Plasmodium falciparum malaria in western Kenya.},
  author={Julie Thwing and Chris Odero and Frank O. Odhiambo and Kephas Otieno and S. G. Kariuki and Rosalynn Ord and Cally Roper and Meredith L McMorrow and John Vulule and Lawrence Slutsker and Robert David Newman and Mary J. Hamel and Meghna Desai},
  journal={Tropical medicine & international health : TM & IH},
  year={2009},
  volume={14 3},
  pages={294-300}
}
OBJECTIVES To assess the efficacy of amodiaquine-artesunate in an area with high chloroquine resistance in western Kenya. METHODS Twenty-eight day in-vivo efficacy trial of amodiaquine-artesunate in 103 children aged 6-59 months in western Kenya with smear-confirmed uncomplicated Plasmodium falciparum malaria. RESULTS The 28-day uncorrected adequate clinical and parasitological response (ACPR) was 69.0%, with 15.5% Late Clinical Failure and 15.5% Late Parasitologic Failure rates. The PCR… CONTINUE READING
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