In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis.

@article{Hoeben2006InVE,
  title={In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis.},
  author={Barbara Jean Hoeben and David S. Burgess and Jason Thomas McConville and Laura K. Najvar and Robert Talbert and Jay I. Peters and Nathan P Wiederhold and Bradi L. Frei and John Richard Graybill and R. Castillo Bocanegra and Kirk A. Overhoff and Prapasri Sinswat and Keith P. Johnston and Robert O Williams},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 4},
  pages={1552-4}
}
Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.